Frontline Plus For Dogs - Red is a topical flea treatment for large dogs. Frontline Plus provides fast, effective, and convenient treatment in a single application. Frontline for big dogs controls fleas, ticks, and chewing lice for dogs weighing 89-132 lbs. Fast-acting and kills ticks, including those that may transmit Lyme disease. Frontline is waterproof so is a great choice for dogs that love the beach, lake, or bath time. Three applications.